My girlfriend has one of these, ethernet-connected to her router and thus available on her home network. However, in order for any computer, Windows or Mac (what about linux?) to access it, it is necessary (aside from any hacky-workarounds that may possibly exist) to install the Iomega Home Storage Manager. This makes volume(s) offered by the NAS appear, on the Mac in Finder under SHARED, or on a Windows machine as additional drive letter(s).
To acquire the Iomega Home Storage Manager, go to https://iomega-eu-en.custhelp.com/app/platform/p/1031,1043 or else try https://iomega-eu-en.custhelp.com/ and click on [Desktop Network Storage > Home Media Network Hard Drive]. May need to establish and login-to an iomega support account (free) first.
I wondered at first about enabling the NAS as a Mac OS Time Machine (backup) disk. An iomega article I saw suggested that should be possible, for iomega firmware 2.0 and above. But the disk as it stands is NTFS-formatted – because when it was set up we had only Windows machines. Now that disk contains much material in that NTFS. I guess it might be possible to partrition the disk e.g. to keep the existing NTFS and add alongside it a HFS+ partition for Time Machine to use. But it’s guesswork that carries risks (of disruption/damage to existing contents). We want an easy geeking-minimal life, so maybe better to repurpose that NAS and get a purpose-made Apple Time Capsule instead. Either way, the evening wears on, so I’ll shelve that idea/investigation for now…